I recently switched to Mac (ironically for audio purposes) and my audio 6 mk2 is not working correctly. It's making the squeal it makes when the driver isn't installed. I did a firmware upgrade on my Windows machine (Mac refused to run the firmware updater) and verified the background processes are running, including several restarts, and granting full disk access.
Running through a hub and dock that works fine with Windows. I'll test running direct when I get a chance.
I'm hoping the answer is not downgrade the OS or buy a new interface, but I'm not sure what else to try.