I have this problem when i try to save my project...
Try Save As. Maybe to a different folder or even disc. Not sure if it may help in Maschine, but it sometimes helps in other programs...
It looks like you're on a PC. Please try to run Maschine as administrator: How to Run a Program as an Administrator
@laked89 Any news on this issue ? Hopefully it is fixed by now? If not, feel free to get in touch here: http://bit.ly/NIsupport_maschine