At the sound level, you can mute just the midi, or the audio as well, which can be quite abrupt, but if it's a long sample - sure.
I can't find any way to have the Group level mute the midi only? Usually that's the mode I prefer - let the loops play out one last time before I make a change. Is this possible? I have a weird memory that my early experience with Maschine was that it only did midi mutes at the group level, so perhaps there is a global setting I am not seeing?