Am I daft? I have the instrument connected. It lights up as it's being hit. When I open any drum machine VST, the Mikro is mute. It will not register any audio hit on any pad. I have been looking this up a long time. No success story for Reaper. I can open the Maschine software fine in Reaper. But I was really hoping this product could serve my need primarily as a 16 pad drum controller for Reaper. My 8 pad Akai keyboard registers MIDI hits from drum machines just fine.